This is a model of the coupled Natch, Wnt and FGF modules as described in:
A. Goldbeter and O. Pourquié, Modeling the segmentation clock as a network of coupled oscillations in the Notch, Wnt and FGF signaling pathways. J Theor Biol. 2008 Jun 7;252(3):574-85, pubmed ID: 18308339
To uncouple the modules remove the reaction MAx_trans_Xa and set vsFK=vsF.
The SBML version of the model was converted from the CellML version by Catherine Lloyd for the CellML repository .

This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2010 The BioModels.net Team.
For more information see the terms of use.
To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Lloyd Catherine c.lloyd@auckland.ac.nz University of Auckland Endler Lukas lukas@ebi.ac.uk EMBL-EBI 2008-11-07T15:03:43Z 2009-06-24T13:00:24Z vsF KIG1 KIG1 K Kt K Rast Rasa ERKt ERKa Xt Xa cytosol epsilon vsN epsilon cytosol vdN N KdN N epsilon cytosol kc N KIF j KIF j F j epsilon cytosol VdNa Na KdNa Na epsilon cytosol kt1 Na kt2 Nan epsilon cytosol VdNan Nan KdNan Nan epsilon cytosol vsFK Nan p KA p Nan p epsilon cytosol vmF MF KdMF MF epsilon cytosol ksF MF epsilon cytosol vdF F KdF F theta cytosol d1 AK a1 A K theta cytosol vsB theta cytosol kd1 B theta cytosol VMK KID KID D B K1 B AK Kt theta cytosol VMP Bp K2 Bp theta cytosol kt4 BN kt3 B theta cytosol kd2 Bp theta cytosol v0 theta cytosol vMB BN n KaB n BN n theta cytosol vMXa Xa m KaXa m Xa m theta cytosol vmd MAx Kmd MAx theta cytosol ksAx MAx theta cytosol vdAx A KdAx A eta cytosol VMaRas Fgf r KaFgf r Fgf r Rasi KaRas Rasi eta cytosol VMdRas Rasa KdRas Rasa eta cytosol VMaErk Rasa Rast ERKi KaErk ERKi eta cytosol kcDusp Dusp ERKa KdErk ERKa eta cytosol VMaX ERKa ERKt Xi KaX Xi eta cytosol VMdX Xa KdX Xa eta cytosol VMsMDusp Xa q KaMDusp q Xa q eta cytosol VMdMDusp MDusp KdMDusp MDusp eta cytosol ksDusp MDusp eta cytosol vdDusp Dusp KdDusp Dusp