This is a CBO-OWL description of a tumor growth with angiogenesis multi-cell model using Compucell3D.
Endothelial-derived short diffusing VEGF isoform.
Glucose (as a representitive limiting nutrient)
Process that describes the creation of the Glucose field.
Process that describes the deletion (consumption, degradation, clearance) of the Gucose field.
GO:vascular endothelial growth factor production
Process for the adhesion of 'Medium' cells to 'Medium' cells.
Process for the adhesion of 'NeoVascular' cells to 'Medium' cells.
Process for the adhesion of 'NeoVascular' cells to 'NeoVascular' cells.
Process for the adhesion of 'NeoVascular' cells to 'Necrotic' cells.
Process for the adhesion of 'NeoVascular' cells to 'Proliferating' cells.
Process for the adhesion of 'NeoVascular' cells to 'Vascular' cells.
Process for the adhesion of 'Necrotic' cells to 'Medium' cells.
Process for the adhesion of 'Necrotic' cells to 'Necrotic' cells.
Process for the adhesion of 'Necrotic' cells to 'Proliferating' cells.
Cell volumetric growth process for cells of type 'necrotic' in which the cell's volume decreases over time.
A proliferating vascular portion. Note that this "cell" type represents a portion of a capilary including both the endothelium and the lumen.
Cell volumetric growth process for cells of type 'NewVascular'.
Mitosis process for the division of a NewVascular cell creating a pair of NewVascular cells.
Process for the adhesion of 'Proliferating' cells to 'Medium' cells.
Process for the adhesion of 'Proliferating' cells to 'Proliferating' cells.
Conversion of a Proliferating cell into Necrotic cell when the cell's glucose level follows below a threshold.
Cell volumetric growth process for cells of type 'Proliferating'.
Mitosis process for the division of a Proliferating cell creating a pair of Proliferating cells.
Need suitable annotations to indicate this is the short diffusing (rapidly degraded in the interstitial space) isoform.
MeSH:Vascular Endothelial Growth Factor A (Medical Subject Headings)
PR:vascular endothelial growth factor A (protein ontology)
Chemotaxis process for cells that chemotax to the VEGF1 field.
Process that describes the creation of the VEGF1 field.
Process that describes the deletion (consumption, degradation, clearance) of the VEGF1 field.
tumor-derived long diffusing VEGF isoform
Chemotaxis process for cells that chemotax to the VEGF2 field.
Process that describes the creation of the VEGF2 field.
Process that describes the deletion (consumption, degradation, clearance) of the VEGF2 field.
Process for the adhesion of 'Vascular' cells to 'Medium' cells.
Process for the adhesion of 'Vascular' cells to 'Necrotic' cells.
Process for the adhesion of 'Vascular' cells to 'Proliferating' cells.
Process for the adhesion of 'Vascular' cells to 'Vascular' cells.
A vascular portion. Note that this "cell" type represents a portion of a capilary including both the endothelium and the lumen.
The top class for our angiogenesis ontology based on CBO.
These are the X, Y and Z extents of the box defining the model's universe.
OWL:CBO description of a Compucell3D model of tumor growth with angiogenesis (blood vessel growth).